Sesquiterpenes from Kadsura coccinea attenuate rheumatoid arthritis-related inflammation by inhibiting the NF-κB and JAK 2 / STAT 3 signal pathways Author Yang, Yupei Author Liu, Yongbei Author Yu, Huanghe Author Xie, Qingling Author Wang, Bin Author Jiang, Sai Author Su, Wei Author Mao, Yu Author Li, Bin Author Peng, Caiyun Author Jian, Yuqing Author Wang, Wei text Phytochemistry 2022 113018 2022-02-28 194 1 9 http://dx.doi.org/10.1016/j.phytochem.2021.113018 journal article 53867 10.1016/j.phytochem.2021.113018 f3a8af98-a2d8-48f0-bed6-f4e332ec436d 1873-3700 8234792

Table 3 Anti-inflammatory and anti-RA activities data of compounds 1–20.

Compounds	Anti-inflammatory cytokines a IC50		Anti-RA activity b IC (μМ) 50
(μМ)
a Inhibitory effects on LPS-stimulated TNF-α and IL-6 generations in LPSinduced RAW 264.7 cells. b Cytotoxicity against RA-FLS cell line. c Positive drug. d No activity.
	TNF-α	IL-6	RA-FLS
2	33.14	2.90	NA d
6	4.59	1.34	NA d
11	1.29	10.10	NA d
13	1.70	12.71	NA d
14	1.03	16.78	NA d
16	NA b	10.99	NA d
18	9.49	NA d	NA d
19	NA d	10.87	9.37
20	1.86	1.66	NA d
methotrexate c	1.10	4.51	4.10