Acute toxicity and antiproliferative and procoagulant activities of fractions derived from Thymus satureioides of the Moroccan High Atlas Author Khouya, T. , & Laboratory of Biochemistry, Department of Biology, Faculty of Sciences & Techniques, University Moulay Ismail, 52000 Errachidia, Morocco Author Ramchoun, M. , & Laboratory of Biochemistry, Department of Biology, Faculty of Sciences & Techniques, University Moulay Ismail, 52000 Errachidia, Morocco & Laboratory of Biotechnology & Sustainable Development of Natural Resources, Polydisciplinary Faculty, 23000 Beni Mellal, Morocco & Laboratory of Biochemistry and Biotechnologies, Department of Biology, Faculty of Sciences, University Mohamed I, 60 000 Oujda, Morocco Author Hmidani, A. , & Laboratory of Biochemistry, Department of Biology, Faculty of Sciences & Techniques, University Moulay Ismail, 52000 Errachidia, Morocco Author El moualij, B. Author Amrani, S. Laboratory of Biochemistry and Biotechnologies, Department of Biology, Faculty of Sciences, University Mohamed I, 60 000 Oujda, Morocco Author Harnafi, H. Laboratory of Biochemistry and Biotechnologies, Department of Biology, Faculty of Sciences, University Mohamed I, 60 000 Oujda, Morocco Author Benlyas, M. , & Laboratory of Biochemistry, Department of Biology, Faculty of Sciences & Techniques, University Moulay Ismail, 52000 Errachidia, Morocco Author Zegzouti, Y. Filali , & Laboratory of Biochemistry, Department of Biology, Faculty of Sciences & Techniques, University Moulay Ismail, 52000 Errachidia, Morocco Author Nazih, E. H. EA- 2160, MMS « Mer, Molécules, Santé », IUML: Institut Universitaire Mer et Littoral FR 3473 CNRS, Faculty of Pharmacy, Nantes, France Author Ouguerram, K. INRA, UMR 1280, Physiologie des Adaptations Nutritionnelles, CHU Hôtel-Dieu, F- 44 000 Nantes, France & CRNH, Western Human Nutrition Research Center, CHU Hôtel-Dieu, F- 44093 Nantes, France Author Alem, C. , & Laboratory of Biochemistry, Department of Biology, Faculty of Sciences & Techniques, University Moulay Ismail, 52000 Errachidia, Morocco text South African Journal of Botany 2019 2019-03-31 121 568 576 http://dx.doi.org/10.1016/j.sajb.2019.01.005 journal article 10.1016/j.sajb.2019.01.005 1727-9321 14036777

Table 7 Effect of CE and polar fractions from T. satureioides on APTT and PT.

Concentration in the clotting mixture [mg/mL]	Crude extract		Methanol fraction		Aqueous fraction
Results are presented as the mean of 6 measurements ± SD and analysed with one-way ANOVA followed by Dunnett's test. * P <.05, ** P <.001. Crude extract, methanol fraction, aqueous fraction vs. control.
	APTT	PT	APTT	PT	APTT	PT
Control	15.35 ± 0.03	14.17 ± 0.01	15.35 ± 0.03	14.25 ± 0.02	15.35 ± 0.03	14.32 ± 0.06
0.18	14.93 ± 0.02*	14.07 ± 0.02*	14.51 ± 0.01**	14.16 ± 0.01	14.55 ± 0.01**	14.23 ± 0.01*
0.36	14.04 ± 0.00*	13.36 ± 0.01**	13.98 ± 0.01**	13.46 ± 0.02**	14.02 ± 0.01**	13.52 ± 0.02**
0.71	13.22 ± 0**	12.75 ± 0.02**	13.15 ± 0.01**	12.83 ± 0.01**	13.19 ± 0.01**	12.9 ± 0.01**
1.43	ND	ND	12.96 ± 0.03**	ND	13.00 ± 0.03**	ND
2.86	ND	ND	ND	ND	ND	ND
5.71	ND	ND	ND	ND	ND	ND
11.43	ND	–	ND	–	ND	–