Natural sucrose esters: Perspectives on the chemical and physiological use of an under investigated chemical class of compounds Author Vargas, Jorge Andrés Mora ∗ & São Paulo State University (UNESP), Institute of Biosciences, Humanities and Exact Sciences, São Jose do Rio Preto, SP, Brazil Author Ortega, Julieth Orduña Author Metzker, Gustavo Author Larrahondo, Jesus Eliecer Author Boscolo, Mauricio text Phytochemistry 2020 112433 2020-09-30 177 1 21 http://dx.doi.org/10.1016/j.phytochem.2020.112433 journal article 10.1016/j.phytochem.2020.112433 1873-3700 8296090

Table 1 Natural sucrose esters with aliphatic substituents and their physiological activities.

Botanical Sources of		NSEs		No.	NSEs name	Physiological activities			References
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Physalis	solanaceus			1 2 3	1′,3′-di- O -isobutyryl-3- O -isovaleryl-2- O -lauroyl sucrose 3′- O -isobutyryl-3- O -isovaleryl-2- O -lauroyl sucrose 3′- O -isobutyryl-3,4-di- O -isovaleryl-2- O -lauroyl sucrose	No physiological activity		determined	Pérez-Castorena et al. (2012)
Physalis	peruviana			4	3,4-di- O -isobutanoyl-3′- O -(isovarelyl)-2- O -dodecanoyl sucrose	Inhibitory effect on the α- amylase enzyme and to explain the hypoglycemic effect and cytotoxicity activity			(Bernal et al., 2018; Cicchetti			et al., 2018)
				5 6 7 8	3,4-di- O -isobutanoyl-2- O -decanoyl-3′- O -(isovareryl) sucrose 2- O -octanoyl-3,3′,4-tri- O -isobutanoylsucrose 2- O -nonanoyl-3,3′,4-tri- O -isobutanoylsucrose 2- O -decanoyl-3,4-di-isobutyryl-3′- O -(2-methylbutanoyl) sucrose
				9	2- O -nonanoyl-3,4-di- O -isobutyryl-3′- O -(3-methylbutanoyl) sucrose
				10 11	2- O -decanoyl-3,3′,4-tri- O -isobutanoyl sucrose. 2- O -dodecanoyl-3,5-di- O -isobutyryl-3′- O -(3-methylbutanoyl) sucrose
				12	2- O -decanoyl-3,5-di- O -isobutyryl-3′- O -(3- methylbutanoyl) sucrose
				13	2- O -nonanoyl-3,3′,5-tri- O -isobutanoyl sucrose
Physalis	alkekengi var. franchetii			14 15 16	3′- O -dodecanoyl-2- O -tigloyl-3- O -isobutyryl sucrose 3′- O -docecanoyl-2- O -(isovarelyl)- 3- O -tigloyl sucrose 3′- O -docecanoyl-2- O -(isovarelyl)-3- O -tigloyl-1′- O -acetyl sucrose	Microbiological activity			(Zhang et al., 2016a,	2017)
				17	1′- O -acetyl-3′- O -dodecanoyl-3- O -isobutyryl-2- O -tigloyl sucrose
				18	1′- O -acetyl-3′- O -dodecanoyl-2- O -isobutyryl-3- O -tigloyl sucrose
				19 20 21	3′- O -tridecanoyl-2,3-di- O -tigloyl sucrose 2- O -(isovarelyl)-3- O -tigloyl sucrose 2, 3-di - O -tigloyl sucrose
Physalis	viscosa			22	2- O -dodecanoyl-3- O -(tigloyl) sucrose	Microbiological activity			Ovenden et al. (2005)
Physalis	nicandroides var. Attenuata			23 24	1′- O -acetyl-2- O -decanoyl-3,3′-di- O -isobutyryl sucrose 1′- O -acetyl-2- O -decanoyl-3- O -isobutyryl-3′- O -(2- methylbutanoyl) sucrose	Protective role in fruits			Maldonado et al. (2006)
				25 26	2- O -decanoyl-3,3′- O -di-isobutyryl sucrose 2- O -decanoyl-3- O -isobutyryl-3′- O -(2-methylbutanoyl) sucrose.
Physalis	peruviana			27	2- O -decanoyl-3,3′,4-tri- O -isobutyry sucrose	Anti-inflammatory	activity		Franco et al. (2014)
Physalis	philadelphica			28 29	2,3-di- O -decanoyl-1′- O -isobutyryl sucrose 2,3-di- O -decanoyl sucrose	Anti-inflammatory	activity		Zhang et al. (2016b)
Physalis	sordida			30 31	3,3′- O -di-isobutiryl-1′- O -acetyl-2- O -lauroyl sucrose 1′- O -acetyl-2- O -lauroyl sucrose	Anti-inflammatory	activity		Pérez-Castorena et al. (2010)
Nicotina tabacum (Solanaceae)				32	Type I-IV (Fig. 4) a	Bio-pesticides			(Ashraf-Khorassani et al., et al., 2006)		2005; Simonovska
Baccharoides guineensis			(Compositae)	33 34	2,3,4,4′,3′- O -pentaisovarelyl sucrose 6′,3′,1′,2- O -tetraisovaleryl sucrose	Antitumor activity			(Toyang et al., 2013,	2012b)