1,3 - Dioxepine and spiropyran derivatives of viomellein and other dimeric naphthopyranones from cultures of Aspergillus elegans KUFA 0015 and their antibacterial activity Author Kumla, Decha * & ICBAS-Instituto de Ciˆencias Biom´edicas Abel Salazar, Rua de Jorge Viterbo Ferreira, 228, 4050 - 313, Porto, Portugal & * & Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leix ˜ oes, Av. General Norton de Matos s / n, 4450 - 208, Matosinhos, Portugal Author Sousa, Emilia * & Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leix ˜ oes, Av. General Norton de Matos s / n, 4450 - 208, Matosinhos, Portugal & Laborat´orio de Química Orgˆanica, Departamento de Ciˆencias Químicas, Faculdade de Farm´acia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050 - 313, Porto, Portugal Author Marengo, Alessia Department of Drug Sciences, Universita`di P´avia, C. So strada Nuova 65, 27100, Pavia, Italy Author Dethoup, Tida Department of Plant Pathology, Faculty of Agriculture, Kasetsart University, Bangkok, 10240, Thailand Author Pereira, A. J. * & ICBAS-Instituto de Ciˆencias Biom´edicas Abel Salazar, Rua de Jorge Viterbo Ferreira, 228, 4050 - 313, Porto, Portugal & * & Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leix ˜ oes, Av. General Norton de Matos s / n, 4450 - 208, Author Gales, Luís * & ICBAS-Instituto de Ciˆencias Biom´edicas Abel Salazar, Rua de Jorge Viterbo Ferreira, 228, 4050 - 313, Porto, Portugal & Instituto de Biologia Molecular e Celular (i 3 S-IBMC), Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050 - 313, Porto, Portugal Author Freitas-Silva, Joana * & ICBAS-Instituto de Ciˆencias Biom´edicas Abel Salazar, Rua de Jorge Viterbo Ferreira, 228, 4050 - 313, Porto, Portugal & * & Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leix ˜ oes, Av. General Norton de Matos s / n, 4450 - 208, Matosinhos, Portugal Author Costa, Paulo M. * & ICBAS-Instituto de Ciˆencias Biom´edicas Abel Salazar, Rua de Jorge Viterbo Ferreira, 228, 4050 - 313, Porto, Portugal & * & Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leix ˜ oes, Av. General Norton de Matos s / n, 4450 - 208, Matosinhos, Portugal Author Mistry, Sharad Department of Chemistry, University of Leicester, University Road, Leicester, LE 7 RH, UK Author Silva, Artur M. S. Departamento de Química & QOPNA, Universidade de Aveiro, 3810 - 193, Aveiro, Portugal Author Kijjoa, Anake * & ICBAS-Instituto de Ciˆencias Biom´edicas Abel Salazar, Rua de Jorge Viterbo Ferreira, 228, 4050 - 313, Porto, Portugal & * & Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leix ˜ oes, Av. General Norton de Matos s / n, 4450 - 208, Matosinhos, Portugal text Phytochemistry 2021 112575 2021-01-31 181 1 15 http://dx.doi.org/10.1016/j.phytochem.2020.112575 journal article 10.1016/j.phytochem.2020.112575 1873-3700 8290910

Table 5 Antibacterial activity of 1–10 against Gram-positive reference and multidrug-resistant strains. Inhibition halos are expressed in mm; MIC and MBC are expressed in μg/ mL.

Compound	E. faecalis ATCC 29212			E. faecalis B3/101 (VRE)			S. aureus ATCC 29213			S. aureus 66/1 (MRSA)
MIC, Minimum Inhibitory Concentration; MBC, Minimum Bactericidal Concentration; (), no inhibition halo.
	Inhibition zone	MIC	MBC	Inhibition zone	MIC	MBC	Inhibition zone	MIC	MBC	Inhibition zone	MIC	MBC
1	–	> 64	> 64	–	> 64	> 64	–	> 64	> 64	–	> 64	> 64
2	–	> 64	> 64	–	> 64	> 64	–	> 64	> 64	–	> 64	> 64
3	10	1–2	1–2	15	1	2–4	10	2	2	14	0.5	0.5–1
4	11	32	> 32	10	≥ 32	> 32	10	16–32	> 32	11	16	32
5	12	8	8	13	> 16	> 16	14	4–8	8	15	2	2–4
6	–	> 64	> 64	–	> 64	> 64	–	> 64	> 64	–	> 64	> 64
8a	–	> 64	> 64	–	> 64	> 64	–	> 64	> 64	–	> 64	> 64
8b	–	> 64	> 64	–	> 64	> 64	–	> 64	> 64	–	> 64	> 64
9a	–	> 64	> 64	–	> 64	> 64	–	> 64	> 64	–	> 64	> 64
9b	8	16	≥ 64	13	16	> 64	10	8	> 64	9	8–16	> 64
9c	–	> 64	> 64	–	> 64	> 64	–	> 64	> 64	–	> 64	> 64
10	–	> 64	> 64	–	> 64	> 64	–	> 64	> 64	–	> 64	> 64