Spirostane saponins with a rearranged A / B ring system isolated from the rhizomes of Ophiopogon japonicus Author Liu, Bo , Bingxin Li &, Gang Chen &, Yingni Pan &, Di Zhou & **, Ning Li & * & School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang, 110016, China Author Li, Bingxin Author Chen, Gang Author Pan, Yingni Author Zhou, Di Author Li, Ning text Phytochemistry 2022 112975 2022-01-31 193 1 9 http://dx.doi.org/10.1016/j.phytochem.2021.112975 journal article 10.1016/j.phytochem.2021.112975 1873-3700 8194415

Table 3 Cytotoxicity effect of compounds against NCI–H460 cell line.

Compounds	IC b (μM) 50	Compounds	IC b (μM) 50
a Cisplatin was used as positive control. b IC: 50% cell viability concentration. (Mean ± SD of 3 tests).
1	> 100	13	> 100
2	> 100	14	27.8 ± 0.5
3	> 100	15	79.8 ± 2.7
4	66.9 ± 1.7	16	> 100
5	> 100	17	30.2 ± 0.8
6	98.7 ± 2.4	18	7.7 ± 0.4
7	> 100	19	2.1 ± 0.8
8	> 100	20	39.0 ± 2.0
9	> 100	21	18.6 ± 1.8
10	> 100	22	4.0 ± 0.8
11	> 100	23	61.8 ± 0.9
12	> 100	Cisplatin a	11.6 ± 0.7