Polyketide-derived macrobrevins from marine macroalga-associated Bacillus amyloliquefaciens as promising antibacterial agents against pathogens causing nosocomial infections Author Chakraborty, Kajal * & Marine Bioprospecting Section of Marine Biotechnology Division, Central Marine Fisheries Research Institute, Ernakulam North, P. B. No. 1603, Cochin, Kerala State, India Author Kizhakkekalam, Vinaya Kizhakkepatt Author Joy, Minju text Phytochemistry 2022 112983 2022-01-31 193 1 13 http://dx.doi.org/10.1016/j.phytochem.2021.112983 journal article 264095 10.1016/j.phytochem.2021.112983 6043f72a-e2ce-44f4-989b-6f8c308815ae 1873-3700 8235151

Table 2 Antibacterial activities of macrobrevin analogues 1–4 and commercial standards against clinical pathogens.

Pathogens	1	2	3	4	Chloramphenicol	Ampicillin
E. coli (MTCC 443)	17b ± 0.05 (6.25)	23 a ± 0.01 (3.12)	29 a ± 0.05 (3.12)	24 a ± 0.10 (6.25)	16b ± 0.02 (6.25)	10 c ± 0.02 (6.25)
V. parahaemolyticus (MTCC 451)	21b ± 0.34 (3.12)	26 a ± 0.05 (1.56)	33 a ± 0.15 (1.56)	26 a ± 0.05 (3.12)	11 c ± 0.06 (6.25)	12 c ± 0.01 (6.25)
P. aeruginosa (ATCC 27853)	19b ± 0.03 (3.12)	13c ± 0.20 (6.25)	23a ± 0.25 (1.56)	22b ± 0.02 (3.12)	11c ± 0.02 (12.50)	11c ± 0.04 (12.50)
K. pneumoniae (ATCC 13883)	11c ± 0.04 (6.25)	16b ± 0.05 (6.25)	25a ± 0.02 (1.56)	24a ± 0.06 (3.12)	7 d ± 0.04 (12.50)	9d ± 0.04 (12.50)
E. tarda (MTCC 2400)	20b ± 0.02 (6.25)	25 a ± 0.05 (3.12)	27 a ± 0.03 (3.12)	27 a ± 0.05 (3.12)	14 c ± 0.01 (6.25)	13 c ± 0.01 (6.25)
S. pyogenes (MTCC, 1924)	22b ± 0.01 (3.12)	21b ± 0.02 (3.12)	30 a ± 0.01 (1.56)	23 a ± 0.02 (6.25)	15 c ± 0.03 (6.25)	15 c ± 0.05 (6.25)
MRSA (ATCC 33592)	20b ± 0.15 (6.25)	22b ± 0.01 (3.12)	24 a ± 0.10 (1.56)	21b ± 0.01 (3.12)	14 c ± 0.02 (6.25)	14 c ± 0.02 (12.50)
VRE fs (ATCC 51299)	22b ± 0.20 (6.25)	24 a ± 0.04 (6.25)	34 a ± 0.05 (1.56)	25 a ± 0.05 (6.25)	8d ± 0.01 (6.25)	11 c ± 0.05 (6.25)