Metabolomic profiling of Zanthoxylum species: Identification of anticholinesterase alkaloids candidates Author Plazas, Erika ∗ & National University of Colombia, Chemistry Department, Cr 30 N ° 45 - 03, 111321, Bogotá, Colombia Author Casoti, Rosana Author Murillo, Monica Avila Author Costa, Fernando Batista Da Author Cuca, Luis Enrique text Phytochemistry 2019 2019-12-31 168 1 13 http://dx.doi.org/10.1016/j.phytochem.2019.112128 journal article 286956 10.1016/j.phytochem.2019.112128 4816f964-45cd-4877-a894-d3c312f9a640 1873-3700 10483700

Table 1 Extracts of Zanthoxylum species analyzed in the metabolomic profiling and tested against AChE and BChE. Extracts showing IC values <100 μg mL −1 were 50 considered active (+).

Sample code	Specie	Place of collection	Part/Extract	IC (μg mL −1) 50
IC 50 values are shown as the mean ± SEM of three independent experiments performed at least in duplicate.
				Ee AChE	Eq BChE
1C	Z. schreberi (J.F. Gmel.) Reynel	Tena	Bark/chloroform	14.11 ± 0.06	44.94 ± 0.49
1A			Bark/aqueous	478.0 ± 2.6	203.5 ± 4.9
2C			Root bark/chloroform	8.44 ± 0.04	28.07 ± 0.24
2A			Root bark/aqueous	206.3 ± 0.8	261.9 ± 8.1
3C			Root/chloroform	24.98 ± 0.11	56.21 ± 0.64
3A			Root/aqueous	623.8 ± 4.4	267.4 ± 7.6
4C	Z. rhoifolium Lam.	Viotá	Root bark/chloroform	9.67 ± 0.05	22.38 ± 0.19
4A			Root bark/aqueous	363.8 ± 2.6	90.23 ± 1.63
5C			Bark/chloroform	24.39 ± 2.50	351.9 ± 2.5
5A			Bark/aqueous	294.2 ± 1.2	> 1000
6C	Z. caribaeum Lam.	Viotá	Bark/chloroform	187.5 ± 1.1	69.71 ± 0,69
6A			Bark/aqueous	334.2 ± 2.0	324.3 ± 0.9
7C			Root/chloroform	92.30 ± 0.80	135.7 ± 1.0
7A			Root/aqueous	206.7 ± 1.6	501.2 ± 1.2
8C	Z. rigidum Humb. & Bonpl. ex Willd	Apulo	Bark/chloroform	246.9 ± 1.3	111.9 ± 1.7
8A			Bark/aqueous	782.1 ± 1.3	359.9 ± 9.4
9C			Root/chloroform	23.33 ± 0.10	45.47 ± 0.42
9A			Root/aqueous	300.8 ± 1.5	110.9 ± 1.5
10C	Z. martinicense ( Lam) DC.	Apulo	Bark/chloroform	24.29 ± 0.17	172.70 ± 2.66
10A			Bark/aqueous	119.5 ± 8.8	30.71 ± 7.74
11C			Root/chloroform	24.29 ± 0.17	48.22 ± 0.41
11A			Root/aqueous	729.0 ± 5.7	> 1000
12C	Zanthoxylum sp	Apulo	Bark/chloroform	36.06 ± 0.24	60.57 ± 0.52
12A			Bark/aqueous	187.2 ± 2.6	245.9 ± 3.6
13C			Root/chloroform	335.8 ± 1.9	131.8 ± 1.2
13A			Root/aqueous	138.0 ± 7.0	171.8 ± 14.6
18C	Z. caribaeum Lam.	Viotá	Bark/chloroform	211.9 ± 1.3	333.5 ± 1.9
18A			Bark/aqueous	207.9 ± 19.1	23.01 ± 1.06
19C			Root/chloroform	67.57 ± 0.37	149.7 ± 0.4
19A			Root/aqueous	76.29 ± 0.58	429.3 ± 0.4
20C	Z. monophyllum (Lam.) P. Wilson	Arbeláez	Root/chloroform	5.01 ± 0.31	130.9 ± 1.4
21C	Z. quinduense Tul.	Tena	Root/chloroform	5.67 ± 0.49	11.40 ± 0.38
21A			Root/aqueous	124.5 ± 10.0	340.9 ± 8.5
22C	Z. fagara (L.) Sarg.	Tocaima	Bark/chloroform	574.4 ± 2.9	142.1 ± 0.8
22A			Bark/aqueous	> 1000	787.6 ± 13.9
23C	Z. rhoifolium Lam.	Guayabal de Siquima	Bark/chloroform	193.2 ± 1.3	138.5 ± 1.3
23A			Bark/aqueous	623.0 ± 7.6	279.5 ± 2.7
24C			Wood/chloroform	344.5 ± 2.8	245.2 ± 2.1
24A			Wood/aqueous	499.1 ± 5.7	> 1000
25C	Z. rhoifolium Lam.	Santa Barbara (S/der)	Bark/chloroform	94.4 ± 0.9	351.9 ± 0.3
25A			Bark/aqueous	657.0 ± 11.2	285.8 ± 3.4