13,13 a-seco-protoberberines from the tubers of Corydalis yanhusuo and their anti-inflammatory activity Author Xia, Gui-Yang , Dong-Jie Fang &, Huan Xia &, Ya-Nan Wang & **, Sheng Lin & * & Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China &, Dong-Jie Fang &, Ling-Yan Wang Author Fang, Dong-Jie Author Wang, Ling-Yan Author Xia, Huan Author Wang, Ya-Nan Author Shang, Hong-Cai Author Lin, Sheng text Phytochemistry 2022 113023 2022-02-28 194 113023 113023 http://dx.doi.org/10.1016/j.phytochem.2021.113023 journal article 10.1016/j.phytochem.2021.113023 1873-3700 8160555

Table 1 1 H NMR data (δ) and 13 C NMR data (δ) of compounds 1 and 2.

No.	1 a		2 a		2 b
a NMR data were measured in DMSO‑ d at 600 MHz for 1 H NMR and at 150 6 MHz for 13 C NMR. Proton coupling constants (J) in Hz are given in parentheses. b NMR data were measured in CDCl at 600 MHz for 1 H NMR and at 150 MHz 3 for 13 C NMR. Proton coupling constants (J) in Hz are given in parentheses.
	δ H	δC	δ H	δC	δ H	δC
1	7.42 s	114.9	7.48 s	110.4	7.66 s	111.2
1a				120.1		121.1
2		148.5		147.7		148.4
3		151.1		152.6		152.9
4	7.26 s	110.4	6.91 s	110.3	6.62 s	109.5
4a		133.7		133.1		132.7
5	5.02 dd (4.9,	63.6	2.81 brs	26.7	2.85 m	27.6
	2.1)
6	4.77 br d (13.1)	62.6	2.91 brs	39.7	3.02 brs	40.3
	5.00 dd (13.1,		3.12 brs		3.24 brs
	4.9)
8	9.96 s	145.1	7.91 brs	81.6	8.03 brs	82.0
8a		121.4		135.6		135.9
9		144.5		143.3		144.2
10		150.7		157.1		157.4
11	8.23 d (9.4)	126.6	7.39	115.9	7.15	115.1
			d (7.8)		d (8.4)
12	8.20 d (9.4)	121.8	7.66	121.5	7.67	122.0
			d (7.8)		d (8.4)
12a		133.6		119.9		121.0
13		130.2		167.9		168.6
13a		136.3		164.1		165.1
13b		118.5
14	3.01 s	18.2
OMe-2	3.87 s	56.7	3.81 s	55.6	3.95 s	56.3
OMe-3	3.91 s	56.4	3.82 s	55.8	3.92 s	56.2
OMe-9	4.11 s	62.5	3.76 s	60.2	3.88 s	61.0
OMe-	4.09 s	57.5	3.94 s	56.6	3.97 s	56.7
10