13,13 a-seco-protoberberines from the tubers of Corydalis yanhusuo and their anti-inflammatory activity Author Xia, Gui-Yang , Dong-Jie Fang &, Huan Xia &, Ya-Nan Wang & **, Sheng Lin & * & Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China &, Dong-Jie Fang &, Ling-Yan Wang Author Fang, Dong-Jie Author Wang, Ling-Yan Author Xia, Huan Author Wang, Ya-Nan Author Shang, Hong-Cai Author Lin, Sheng text Phytochemistry 2022 113023 2022-02-28 194 113023 113023 http://dx.doi.org/10.1016/j.phytochem.2021.113023 journal article 10.1016/j.phytochem.2021.113023 1873-3700 8160555

Table 2 1 H NMR data (δ) and 13 C NMR data (δ) of compounds 3 6 in DMSO‑ d a. – 6

No.	3		4		5		6
a The assignments were based on 1 H– 1 H COSY, HSQC, HMBC and NOESY experiments.
	δ H	δC	δ H	δC	δ H	δC	δ H	δC
1	7.36 s	110.0	7.53 s	107.4	7.37 s	110.0	7.24 s	110.4
1a		121.5		119.5		121.6		120.0
2		147.4		149.0		147.4		147.9
3		151.4		153.4		151.4		153.2
4	6.81 s	110.0	7.09 s	106.9	6.81 s	110.1	6.99 s	110.2
4a		132.0		132.6		132.0		135.0
5	2.73 t (6.6)	27.1	6.44 d (7.4)	104.3	2.72 t (6.7)	27.1	2.98 m	26.8
							3.05 m
6	3.31 t (6.6)	45.3	7.08 d (7.4)	131.7	3.28 t (6.7)	44.8	4.04 m	41.3
							4.31 m
8	4.79 s	41.5	5.20 s	44.4	4.82 s	41.3		168.4
8a		129.9		129.2		130.5		134.7
9		148.1		148.7		147.4		143.4
10		154.5		155.1		153.1		156.1
11	7.09 d (8.4)	111.2	7.13 d (8.7)	112.2	6.90 d (8.4)	115.2	7.12 d (8.7)	111.0
12	7.54 d (8.4)	125.2	7.65 d (8.7)	125.9	7.44 d (8.4)	125.8	7.81 d (8.7)	127.7
12a		133.3		133.8		131.7		126.6
13		201.1		201.3		200.6		195.9
13a		163.4		160.8		163.3		163.4
14	2.51 s	29.7	2.57	29.9	2.48 s	29.6	2.45 s	26.5
OMe-2	3.76 s	55.5	3.84 s	55.9	3.76 s	55.5	3.70 s	55.4
OMe-3	3.78 s	55.6	3.86 s	56.1	3.78 s	55.6	3.85 s	55.9
OMe-9	3.72 s	60.1	3.56 s	60.3	3.71 s	59.8	3.60 s	60.3
OMe-10	3.87 s	55.8	3.86 s	56.4			3.92 s	56.1
OH-10					10.19 s