In vitro cytotoxicity and structure-activity relationship approaches of entkaurenoic acid derivatives against human breast carcinoma cell line Author da Costa, Ricardo M. ∗∗ & ∗ & Núcleo de Pesquisa em Ciências Exatas e Tecnológicas da Universidade de Franca - UNIFRAN, Franca, SP, Brazil & Informática Aplicada às Ciências - IFSULDEMINAS, Muzambinho, MG, Brazil Author Bastos, Jairo K. Author Costa, Maria C. A. Author Ferreira, Márcia M. C. Author Mizuno, Cássia S. Author Caramori, Giovanni F. Author Nagurniak, Gláucio R. Author Simão, Marília R. Author dos Santos, Raquel A. Author Veneziani, Rodrigo C. S. Author Ambrósio, Sérgio R. Author Parreira, Renato L. T. text Phytochemistry 2018 2018-10-12 156 214 223 http://dx.doi.org/10.1016/j.phytochem.2018.10.005 journal article 10.1016/j.phytochem.2018.10.005 1873-3700 10484535

Table 1 IC (μmol L −1) and p IC values (mol L −1) for compounds 1–27 against MCF-7 50 50 breast cells.

Compounds	IC / a p IC 50 50	Compounds	IC / a p IC 50 50
a p IC means –logIC (IC in mol L −1). 50 50 50 b Synthesized compound.
1	145.40/3.84	15	288.00/3.54
2	141.00/3.85	16	392.60/3.41
3	505.90/3.30	17	630.20/3.20
4	783.00/3.11	18	873.00/3.06
5	805.10/3.09	19	7.84/5.11
6	251.90/3.60	20	17.26/4.76
7	151.00/3.82	21	42.89/4.37
8	165.20/3.78	22	64.92/4.19
9	257.00/3.59	23	66.47/4.18
10	151.60/3.82	24	68.01/4.17
11	49.80/4.30	25	94.32/4.03
12	69.10/4.16	26	136.00/3.87
13	216.40/3.66	27	b
14	219.50/3.66