A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids Author Shi, Shaochun , Jichong Li &, Xuemei Zhao &, Qingbo Liu & **, Shao-Jiang Song & * & Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, China Author Li, Jichong Author Zhao, Xuemei Author Liu, Qingbo Author Song, Shao-Jiang text Phytochemistry 2021 112895 2021-11-30 191 1 56 http://dx.doi.org/10.1016/j.phytochem.2021.112895 journal article 10.1016/j.phytochem.2021.112895 1873-3700 8194277

Table 12 Occurrence and enzyme inhibition of prenylated flavonoids.

NO.	Name of compounds	Bioactivity (μM)	Origin	References
(continued on next page)
33	Kuwanon C	Tyrosinase inhibition (54% inhibition at 30 μM)	Echinosophora koreensis Nakai	Lee et al. (2004)
			Berberidaceae
77	Cyclomulberrin	Tyrosinase inhibition: IC 50 = 66.30	Morus alba Moraceae	Zhang et al. (2016)
495	Broussochalcone A	Tyrosinase inhibition (3% inhibition at 30 μM)	Echinosophora koreensis Nakai	Lee et al. (2004)
			Berberidaceae
496	Isosophoranone	Tyrosinase inhibition: IC 50 > 50	Echinosophora koreensis Nakai	Lee et al. (2004)
			Berberidaceae
497	Kazinol B	Tyrosinase inhibition (15% inhibition at 30 μM)	Echinosophora koreensis Nakai	Lee et al. (2004)
			Berberidaceae
12	Papyriflavonol A	Tyrosinase inhibition (16% inhibition at 30 μM)	Echinosophora koreensis Nakai	Lee et al. (2004)
			Berberidaceae	Jin et al. (2010)
498	Sanggenon D	Tyrosinase inhibition (91% inhibition at 30 μM)	Echinosophora koreensis Nakai	Lee et al. (2004)
			Berberidaceae
499	Sophoflavescenol	Tyrosinase inhibition (30% inhibition at 30 μM)	Echinosophora koreensis Nakai	Lee et al. (2004)
			Berberidaceae
78	Cyclomorusin	Tyrosinase inhibition: IC50 > 300.0	Artocarpus altilis Moraceae	Lan et al. (2013)
329	()-Cudraflavone A	Tyrosinase inhibition: IC50 = 88.4	Artocarpus altilis Moraceae	Lan et al. (2013)
434	10-Oxoartogomezianone	Tyrosinase inhibition: IC50 > 300.0	Artocarpus altilis Moraceae	Lan et al. (2013)
435	8-Geranyl-3-(hydroxyprenyl)	Tyrosinase inhibition: IC50 > 300.0	Artocarpus altilis Moraceae	Lan et al. (2013)
isoetin
436	Isocycloartobiloxanthone	Tyrosinase inhibition: IC50 = 279.5	Artocarpus altilis Moraceae	Lan et al. (2013)
437	Furanocyclocommunin	Not tested	Artocarpus altilis Moraceae	Lan et al. (2013)
438	8-Geranylapigenin	Tyrosinase inhibition: IC50 > 300.0	Artocarpus altilis Moraceae	Lan et al. (2013)
439	Artocarpin	Tyrosinase inhibition: IC50 = 270.3	Artocarpus altilis Moraceae	Lan et al. (2013)
440	Artogomezianone	Tyrosinase inhibition: IC50 = 84.8	Artocarpus altilis Moraceae	Lan et al. (2013)
441	Cyclocommunol	Tyrosinase inhibition: IC50 = 209.1	Artocarpus altilis Moraceae	Lan et al. (2013)