{"uuid": "DF67D1E2FFE4A81C515212D7E368FF17","caption": "Table 13 The enzymatic activity of compounds against PDE4 (IC 50, μM).","headers": [{"NO.": "537","R1": "H","R2": "H","R3": "α- H","IC (μM)b 50": "0.0054 ± 0.0003"},{"NO.": "538","R1": "H","R2": "H","R3": "β- H","IC (μM)b 50": "0.25 ± 0.01"},{"NO.": "539","R1": "–","R2": "–","R3": "–","IC (μM)b 50": "0.02 ± 0.002"},{"NO.": "441","R1": "–","R2": "–","R3": "–","IC (μM)b 50": "0.40 ± 0.03"},{"NO.": "540","R1": "–","R2": "–","R3": "–","IC (μM)b 50": "0.04 ± 0.003"},{"NO.": "541","R1": "–","R2": "–","R3": "–","IC (μM)b 50": "0.87 ± 0.03"},{"NO.": "542","R1": "–","R2": "–","R3": "–","IC (μM)b 50": "3.59 ± 0.17"},{"NO.": "543","R1": "–","R2": "–","R3": "–","IC (μM)b 50": "0.03 ± 0.002"},{"NO.": "544","R1": "–","R2": "–","R3": "–","IC (μM)b 50": "0.63 ± 0.04"},{"NO.": "545","R1": "–","R2": "–","R3": "–","IC (μM)b 50": "0.27 ± 0.01"},{"NO.": "79","R1": "–","R2": "–","R3": "–","IC (μM)b 50": "0.90 ± 0.04"},{"NO.": "546","R1": "–","R2": "–","R3": "–","IC (μM)b 50": "2.33 ± 0.12"},{"NO.": "294","R1": "–","R2": "–","R3": "–","IC (μM)b 50": "1.26 ± 0.09"},{"NO.": "547","R1": "–","R2": "–","R3": "–","IC (μM)b 50": "2.91 ± 0.13"},{"NO.": "548","R1": "–","R2": "–","R3": "–","IC (μM)b 50": "9.90 ± 0.40"},{"NO.": "33","R1": "–","R2": "–","R3": "–","IC (μM)b 50": "0.31 ± 0.02"},{"NO.": "549","R1": "–","R2": "–","R3": "–","IC (μM)b 50": "0.26 ± 0.02"},{"NO.": "550","R1": "–","R2": "–","R3": "–","IC (μM)b 50": "1.88 ± 0.10"},{"NO.": "551","R1": "CH3","R2": "CH3","R3": "β- H","IC (μM)b 50": "–"},{"NO.": "552","R1": "H","R2": "CH3","R3": "β- H","IC (μM)b 50": "5.18 ± 0.13"},{"NO.": "553","R1": "H","R2": "Ac","R3": "β- H","IC (μM)b 50": "4.89 ± 0.20"},{"NO.": "554","R1": "H","R2": "tosyl","R3": "β- H","IC (μM)b 50": "–"},{"NO.": "555","R1": "H","R2": "p -bromobenzoyl","R3": "β- H","IC (μM)b 50": "–"},{"NO.": "556","R1": "H","R2": "naphthalene-2-sulfonyl","R3": "β- H","IC (μM)b 50": "–"},{"NO.": "557","R1": "thiophene-2-carbonyl","R2": "thiophene-2-carbonyl","R3": "β- H","IC (μM)b 50": "–"},{"NO.": "558","R1": "CH3","R2": "CH3","R3": "α- H","IC (μM)b 50": "–"},{"NO.": "559","R1": "H","R2": "disilane","R3": "α- H","IC (μM)b 50": "8.60 ± 0.31"},{"NO.": "560","R1": "–","R2": "–","R3": "β- H","IC (μM)b 50": "–"},{"NO.": "561","R1": "–","R2": "–","R3": "α- H","IC (μM)b 50": "4.35 ± 0.11"},{"NO.": "562","R1": "–","R2": "–","R3": "–","IC (μM)b 50": "7.50 ± 0.34"},{"NO.": "563","R1": "–","R2": "–","R3": "–","IC (μM)b 50": "9.21 ± 0.33"},{"NO.": "Rolipram c","R1": "–","R2": "–","R3": "–","IC (μM)b 50": "0.62 ± 0.03"}],"footers": []}